Inflammation and Allergy Drug Design

Our knowledge and understanding of allergic diseases of the respiratory tract has improved to a point where new therapies are being developed for patient benefit.

Inflammation and Allergy Drug Design explains the biologic science that underpins the pathophysiology of asthma and related disorders, as well as their mechanisms. This authoritative guide consists of 25 chapters, each detailing the cutting-edge developments in a particular field. It is divided into three parts, covering cytokines, chemokines, grow factors and mediators.

This book allows immunologists, allergologists and researchers in the pharmaceutical industry to learn and appreciate the target biology in drug development. It also provides medical and pharmaceutical postgraduate
students and clinicians with a basic understanding of allergic diseases in the respiratory tract.

Content:
Chapter 1 Novel Anti?Inflammatory Drugs Based on Targeting Lung Dendritic Cells and Airway Epithelial Cells (pages 1–14): Bart N. Lambrecht, Maud Plantinga, Monique Willart and Hamida Hammad
Chapter 2 Role of Th2 Cells in the Allergic Diathesis (pages 15–25): Marsha Wills?karp
Chapter 3 Importance of Th17? and Th1?Associated Responses for the Development of Asthma (pages 27–38): Tomohiro Yoshimoto, Hiroko Tsutsui and Kenji Nakanishi
Chapter 4 Regulatory T Cells (pages 39–57): Chris Corrigan and Kimuli Ryanna
Chapter 5 A Role for Natural Killer T?Cell Subsets in the Pathogenesis of Various Allergic Disorders (pages 59–66): Hiroshi Watarai, Michishige Harada, Mayumi Tamari and Masaru Taniguchi
Chapter 6 Regulatory Roles of B Cells in Allergy and Inflammation (pages 67–77): Kiyoshi Takatsu, Masashi Ikutani and Yoshinori Nagai
Chapter 7 Mast Cells (pages 79–105): Mindy Tsai and Stephen J. Galli
Chapter 8 Eosinophils (pages 107–121): Nancy A. Lee, Mark V. Dahl, Elizabeth A. Jacobsen and Sergei I. Ochkur
Chapter 9 Basophils in Inflammation and Allergy Drug Design (pages 123–137): Donald MacGlashan
Chapter 10 Epithelial Cells (pages 139–148):